If you have relatively small items of very high value, it is worth considering a safe.
Safes are available in a range of sizes and often come with pre-drilled holes allowing permanent mounting to any surface.
If desired there are also safes that can withstand fire or water for a specified period of time. Some safes can be opened manually with a key and others have a keypad for which you will have a personal code.
Yale has various safes suitable for the home from electronic keypad operated laptop safes to key operated underfloor safes. See the product section for further details.